Crofton Research Laboratory
PUBLICATIONS
Alcohol and the Amygdala​
Crofton EJ, O’Buckley TK, Bohnsack JP, Morrow AL, Herman MA. (2023). Divergent population-specific effects of chronic ethanol exposure on excitability and inhibitory transmission in male and female rat central amygdala. Journal of Neuroscience. 43, 42. 7056-7068. doi: 10.1523/jneurosci.0717-23.2023.
Crofton EJ, Zhu M, Curtis KN, Nolan GW, O’Buckley TK, Morrow AL, Herman MA. (2022). Medial prefrontal cortex-basolateral amygdala circuit dysfunction in chronic alcohol-exposed male rats. Neuropharmacology. 205, 108912. Underline indicates EC undergraduate student. doi: 10.1016/j.neuropharm.2021.108912. PMC8800149.
Alcohol and the Prefrontal Cortex
Hughes BA, Crofton EJ, O’Buckley TK, Herman MA, Morrow AL. (2019). Chronic ethanol exposure alters prelimbic prefrontal cortical Fast-Spiking and Martinotti interneuron function with differential sex specificity in rat brain. Neuropharmacology. doi: 10.1016/j.neuropharm.2019.107805. PMID31589884.
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Retinoic Acid Signaling and Cocaine
Crofton EJ*, Nenov MN*, Zhang Y*, Tapia CM, Donnelly J, Koshy S, Laezza F, Green TA. (2021). Topographic transcriptomics of the nucleus accumbens shell: Identification and validation of fatty acid binding protein 5 as target for cocaine addiction. Neuropharmacology. 183, 108398. *these authors contributed equally. doi: 10.1016/j.neuropharm.2020.108398. PMC7755097.
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Zhang Y*, Crofton EJ*, Fan X, Li D, Kong F, Sinha M, Luxon BA, Spratt HM, Lichti CF, Green TA. (2016). Convergent transcriptomics and proteomics of environmental enrichment and cocaine identifies novel therapeutic strategies for addiction. Neuroscience. 339, 254-266. *these authors contributed equally. doi: 10.1016/j.neuroscience.2016.09.051. PMC5118094.
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Zhang Y, Kong F, Crofton EJ, Sinha M, Li D, Fan X, Hommel JD, Spratt HM, Luxon BA, Green TA. (2016). Transcriptomics of environmental enrichment reveals a role for retinoic acid signaling in addiction. Frontiers in Molecular Neuroscience, 9, 119. doi: 10.3389/fnmol.2016.00119. PMC5110542.
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Retinoic Acid Signaling and Depression
Zhang Y, Crofton EJ, Smith TES, Koshy S, Li D, Green TA. (2019). Manipulation of retinoic acid signaling in the nucleus accumbens shell alters rat emotional behavior. Behavioural Brain Research. doi: 10.1016/j.bbr.2019.112177. PMID31449909.​
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Glycogen Synthase Kinase 3 Beta
Scala F*, Nenov MN*, Crofton EJ, Singh AK, Folorunso O, Zhang Y, Chesson BC, Wildburger NC, James TF, Alshammari M, Alshammari T, Elfrink H, Grassi C, Lichti C, Rudra JS, D’Ascenzo M, Green TA, Laezza F. (2018). Environmental enrichment and social isolation mediate neuroplasticity of medium spiny neurons through the GSK3 pathway. Cell Reports. 23(2), 555-567. *these authors contributed equally. doi: 10.1016/j.celrep.2018.03.062. PMC6150488.​
Crofton EJ, Nenov MN, Zhang Y, Scala F, Page SA, Li D, Hommel JD, Laezza F, Green TA. (2017). Glycogen synthase kinase 3 beta alters anxiety-, depression-, and addiction-related behaviors and neuronal activity in the nucleus accumbens shell. Neuropharmacology. 117, 49-60. doi: 10.1016/j.neuropharm.2017.01.020. PMC5386787.
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Delta Fos B​
Zhang Y, Crofton EJ, Li D, Fan X, Nestler EJ, Green TA. (2014). Overexpression of DeltaFosB in nucleus accumbens mimics the protective addiction phenotype, but not the protective depression phenotype of environmental enrichment. Frontiers in Behavioral Neuroscience. 8. 297. doi: 10.3389/fnbeh.2014.00297. PMC4148937.
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Review Articles
Agoglia AE*, Crofton EJ*, Herman MA. (2020). Biological intersection of sex, age, and environment in the corticotropin releasing factor (CRF) system and alcohol. Neuropharmacology. (170). *these authors contributed equally. doi: 10.1016/j.neuropharm.2020.108045. PMC7350391.
Crofton EJ, Zhang Y, Green TA. (2015). Inoculation stress model of environmental enrichment, Neuroscience and Biobehavioral Reviews. 49c: 19-31. doi: 10.1016/j.neubiorev.2014.11.017. PMC4305384.
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